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\documentclass[letterpaper]{article} \documentclass[letterpaper]{article}
\usepackage[T1]{fontenc} \usepackage[T1]{fontenc}
\usepackage{geometry} \usepackage{geometry}
\geometry{margin = 1in} \geometry{margin = 1in}
\usepackage{setspace} \usepackage{setspace}
\usepackage{chemfig} \usepackage{chemfig}
\usepackage[style = chem-acs]{biblatex} \usepackage[style = chem-acs]{biblatex}
\addbibresource{references.bib} \addbibresource{references.bib}
\usepackage{graphicx} \usepackage{graphicx}
\usepackage{float} \usepackage{float}
\newfloat{scheme}{htbp}{los} \newfloat{scheme}{htbp}{los}
\floatname{scheme}{Scheme} \floatname{scheme}{Scheme}
\floatname{chart}{Chart} \floatname{chart}{Chart}
\newfloat{graph}{htbp}{loh} \newfloat{graph}{htbp}{loh}
\usepackage{chemformula} % Formulas using \ch{} \usepackage{chemformula} % Formulas using \ch{}
% or % or
\usepackage[version = 4]{mhchem} % Formulas using \ce{} \usepackage[version = 4]{mhchem} % Formulas using \ce{}
\setcounter{secnumdepth}{-1} \setcounter{secnumdepth}{-1}
\newcommand*\mycommand[1]{\texttt{\emph{#1}}} \newcommand*\mycommand[1]{\texttt{\emph{#1}}}
\usepackage{authblk} \usepackage{authblk}
\author[1]{Shivam Tripathi} \author[1]{Shivam Tripathi}
\author[1]{Keshav Anand} \author[1]{Keshav Anand}
\affil[1]{Plano East Senior High School, Plano, TX, United States} \affil[1]{Plano East Senior High School, Plano, TX, United States}
\title{Acid-Catalyzed Tandem Hydrolysis--Esterification of Acetylsalicylic Acid \title{Acid-Catalyzed Tandem Hydrolysis--Esterification of Acetylsalicylic Acid
from Commerical Asprin Tablets to Form Methyl Salicylate} from Commerical Asprin Tablets to Form Methyl Salicylate}
% Use the \date command for email address(s) of corresponding authors % Use the \date command for email address(s) of corresponding authors
\begin{document} \begin{document}
\maketitle \maketitle
\begin{abstract} \begin{abstract}
This is an example document for creating \LaTeX{} submissions to the American Methyl salicylate was synthesized from commercial aspirin tablets via an acid-catalyzed
Chemical Society (ACS) for publication. As ACS does not use \LaTeX{} for tandem hydrolysis–esterification sequence. Acetylsalicylic acid (ASA) was extracted
typesetting accepted manuscripts, this template does not seek to from the tablet matrix into methanol and reacted under reflux with a catalytic
reproduce the appearance of a published paper. volume of \ce{H2SO4}. This one-pot method facilitates simultaneous deacetylation
\end{abstract} and Fischer esterification, bypassing the isolation of a salicylic acid intermediate.
The resulting methyl salicylate was isolated via aqueous quenching and
liquid--liquid extraction. Crude product purification was achieved through
\section{Introduction} neutralization with saturated \ce{NaHCO3} and drying over anhydrous \ce{MgSO4}.
This synthesis demonstrates an efficient, high-yield conversion of a common
Acetylsalicylic acid (ASA), \ch{C9H8O4}, is a synthetic organic derivative of salicylic acid pharmaceutical precursor into a high-value fragrance ester, highlighting
and is commonly known as aspirin~\cite{Fijakowski2022}.\\ fundamental principles of equilibrium-driven organic transformations and
\begin{figure}[ht] multistep one-pot synthesis.
\centering \end{abstract}
\vspace{1em} % Adds space above the molecule
\chemfig{*6(-=-(-O-[:-30](=[:-90]O)-[:+30]CH_3)=([:60]-[:90](=[:150]O)-[:30]OH)-=)}
\vspace{1em} % Adds space below the molecule \section{Introduction}
\caption{Chemical structure of ASA}
\label{fig:asa-structure} Acetylsalicylic acid (ASA), \ch{C9H8O4}, is a synthetic organic derivative of salicylic acid
\end{figure} and is commonly known as aspirin~\cite{Fijakowski2022}.\\
\begin{figure}[ht]
Commercial aspirin is commonly synthesized from salicylic acid through Eq~\ref{eq:aspirin-syn}, \centering
and the two molecules differ by an ester group (\ch{-OCOCH3})~\cite{Sneader2000}. \vspace{1em} % Adds space above the molecule
\begin{equation} \chemfig{*6(-=-(-O-[:-30](=[:-90]O)-[:+30]CH_3)=([:60]-[:90](=[:150]O)-[:30]OH)-=)}
\ce{C7H6O3 + C4H6O3 ->[H2SO4] C9H8O4 + CH3COOH} \vspace{1em} % Adds space below the molecule
\label{eq:aspirin-syn} \caption{Chemical structure of ASA}
\end{equation} \\ \label{fig:asa-structure}
Another common derivative product of salicylic acid is methyl salicylate, \ch{C8H8O3}, commonly referred to \end{figure}
as wintergreen oil. Methyl salicylate is commonly used in edibles (e.g. gum, mints), perfumes, and pain-relief
ointments (e.g. Icy Hot, BenGay)~\cite{Guo2022}. Methyl salicylate also differs with salicylic acid by a single ester group and Commercial aspirin is commonly synthesized from salicylic acid through Eq~\ref{eq:aspirin-syn},
has simply been esterified differently than ASA.\\ and the two molecules differ by an ester group (\ch{-OCOCH3})~\cite{Sneader2000}.
\begin{equation}
\begin{figure}[ht] \ce{C7H6O3 + C4H6O3 ->[H2SO4] C9H8O4 + CH3COOH}
\centering \label{eq:aspirin-syn}
\vspace{1em} % Adds space above the molecule \end{equation} \\
\chemfig{*6(-=-(-OH)=([:60]-[:90](=[:150]O)-[:30]O-[:+90]CH_3)-=)} Another common derivative product of salicylic acid is methyl salicylate, \ch{C8H8O3}, commonly referred to
\vspace{1em} % Adds space below the molecule as wintergreen oil. Methyl salicylate is commonly used in edibles (e.g. gum, mints), perfumes, and pain-relief
\caption{Chemical structure of methyl salicylate} ointments (e.g. Icy Hot, BenGay)~\cite{Guo2022}. Methyl salicylate also differs with salicylic acid by a single ester group and
\label{fig:methyl-salicylate} has simply been esterified differently than ASA.\\
\end{figure}
\begin{figure}[ht]
Due to the similarity between the two molecules, ASA can be reacted to synthesize methyl salicylate~\cite{Hartel2009}. \centering
The purpose of this experiment was to convert acetylsalicylic acid obtained from \vspace{1em} % Adds space above the molecule
commercial aspirin tablets into methyl salicylate through acid-catalyzed esterification \chemfig{*6(-=-(-OH)=([:60]-[:90](=[:150]O)-[:30]O-[:+90]CH_3)-=)}
in methanol under reflux conditions. \vspace{1em} % Adds space below the molecule
\caption{Chemical structure of methyl salicylate}
\label{fig:methyl-salicylate}
\section{Results and discussion} \end{figure}
\subsection{Outline} Due to the similarity between the two molecules, ASA can be reacted to synthesize methyl salicylate~\cite{Hartel2009}.
The purpose of this experiment was to convert acetylsalicylic acid obtained from
The document layout should follow the style of the journal concerned. Where commercial aspirin tablets into methyl salicylate through acid-catalyzed esterification
appropriate, sections and subsections should be added in the normal way. in methanol under reflux conditions.
\subsection{References}
\section{Results and discussion}
References should be given in the normal way in \LaTeX{}. If you are using
\textsf{biblatex} (as recommended) then you can use the full range of citation \subsection{Outline}
commands it provides. If you choose to use classical Bib\TeX{}, the
\textsf{natbib} package will be loaded and you can use it's commands. The document layout should follow the style of the journal concerned. Where
appropriate, sections and subsections should be added in the normal way.
\subsection{Floats}
\subsection{References}
New float types are set up in the preamble. The means graphics are included as
follows (Scheme~\ref{sch:example}). As illustrated, the float is ``here'' if References should be given in the normal way in \LaTeX{}. If you are using
possible. \textsf{biblatex} (as recommended) then you can use the full range of citation
\begin{scheme} commands it provides. If you choose to use classical Bib\TeX{}, the
\centering \textsf{natbib} package will be loaded and you can use it's commands.
Your scheme graphic would go here: PDF graphics are recommended.
%\includegraphics{graphic} \subsection{Floats}
\caption{An example scheme}
\label{sch:example} New float types are set up in the preamble. The means graphics are included as
\end{scheme} follows (Scheme~\ref{sch:example}). As illustrated, the float is ``here'' if
possible.
\begin{scheme}
\centering
The use of the different floating environments is not required, but it is Your scheme graphic would go here: PDF graphics are recommended.
intended to make document preparation easier for authors. In general, you %\includegraphics{graphic}
should place your graphics where they make logical sense; the production \caption{An example scheme}
process will move them if needed. \label{sch:example}
\end{scheme}
\subsection{Math}
If packages such as \textsf{amsmath} are required, they should be loaded in the
preamble. However, the basic \LaTeX\ math(s) input should work correctly The use of the different floating environments is not required, but it is
without this. Some inline material $1 + 1 = 2$ followed by some display. \[ A = intended to make document preparation easier for authors. In general, you
\pi r^2 \] should place your graphics where they make logical sense; the production
process will move them if needed.
It is possible to label equations in the usual way (Eq.~\ref{eqn:example}).
\begin{equation} \subsection{Math}
\frac{\mathrm{d}}{\mathrm{d}x} \, r^2 = 2r \label{eqn:example}
\end{equation} If packages such as \textsf{amsmath} are required, they should be loaded in the
This can also be used to have equations containing graphical content. To align preamble. However, the basic \LaTeX\ math(s) input should work correctly
the equation number with the middle of the graphic, rather than the bottom, a without this. Some inline material $1 + 1 = 2$ followed by some display. \[ A =
minipage may be used. \pi r^2 \]
\begin{equation}
\begin{minipage}[c]{0.80\linewidth} It is possible to label equations in the usual way (Eq.~\ref{eqn:example}).
\centering \begin{equation}
As illustrated here, the width of \\ \frac{\mathrm{d}}{\mathrm{d}x} \, r^2 = 2r \label{eqn:example}
the minipage needs to allow some \\ \end{equation}
space for the number to fit in to. This can also be used to have equations containing graphical content. To align
%\includegraphics{graphic} the equation number with the middle of the graphic, rather than the bottom, a
\end{minipage} minipage may be used.
\label{eqn:graphic} \begin{equation}
\end{equation} \begin{minipage}[c]{0.80\linewidth}
\centering
\section{Experimental} As illustrated here, the width of \\
the minipage needs to allow some \\
The usual experimental details should appear here. This could include a table, space for the number to fit in to.
which can be referenced as Table~\ref{tbl:example}. Notice that the caption is %\includegraphics{graphic}
positioned at the top of the table. \end{minipage}
\begin{table} \label{eqn:graphic}
\caption{An example table} \end{equation}
\label{tbl:example}
\centering \section{Experimental}
\begin{tabular}{ll}
\hline The usual experimental details should appear here. This could include a table,
Header one & Header two \\ which can be referenced as Table~\ref{tbl:example}. Notice that the caption is
\hline positioned at the top of the table.
Entry one & Entry two \\ \begin{table}
Entry three & Entry four \\ \caption{An example table}
Entry five & Entry five \\ \label{tbl:example}
Entry seven & Entry eight \\ \centering
\hline \begin{tabular}{ll}
\end{tabular} \hline
\end{table} Header one & Header two \\
\hline
Adding notes to tables can be complicated. Perhaps the easiest method is to Entry one & Entry two \\
generate these using the basic \texttt{\textbackslash textsuperscript} and Entry three & Entry four \\
\texttt{\textbackslash emph} macros, as illustrated (Table~\ref{tbl:notes}). Entry five & Entry five \\
\begin{table} Entry seven & Entry eight \\
\caption{A table with notes} \hline
\label{tbl:notes} \end{tabular}
\centering \end{table}
\begin{tabular}{ll}
\hline Adding notes to tables can be complicated. Perhaps the easiest method is to
Header one & Header two \\ generate these using the basic \texttt{\textbackslash textsuperscript} and
\hline \texttt{\textbackslash emph} macros, as illustrated (Table~\ref{tbl:notes}).
Entry one\textsuperscript{\emph{a}} & Entry two \\ \begin{table}
Entry three\textsuperscript{\emph{b}} & Entry four \\ \caption{A table with notes}
\hline \label{tbl:notes}
\end{tabular} \centering
\begin{tabular}{ll}
\textsuperscript{\emph{a}} Some text; \hline
\textsuperscript{\emph{b}} Some more text. Header one & Header two \\
\end{table} \hline
Entry one\textsuperscript{\emph{a}} & Entry two \\
The example file also loads the optional \textsf{chemformula} and Entry three\textsuperscript{\emph{b}} & Entry four \\
\textsf{mhchem} packages, so that formulas are easy to input: \hline
\texttt{\textbackslash ce\{H2SO4\}} gives \ce{H2SO4}. The two have similar \end{tabular}
syntax but authors may prefer one or the other.
\textsuperscript{\emph{a}} Some text;
The use of new commands should be limited to simple things which will not \textsuperscript{\emph{b}} Some more text.
interfere with the production process. For example, \texttt{\textbackslash \end{table}
mycommand} has been defined in this example, to give italic, mono-spaced text:
\mycommand{some text}. The example file also loads the optional \textsf{chemformula} and
\textsf{mhchem} packages, so that formulas are easy to input:
\section*{Acknowledgements} \texttt{\textbackslash ce\{H2SO4\}} gives \ce{H2SO4}. The two have similar
syntax but authors may prefer one or the other.
Please use ``The authors thank \ldots'' rather than ``The authors would like to
thank \ldots''. The use of new commands should be limited to simple things which will not
interfere with the production process. For example, \texttt{\textbackslash
\section*{Supporting information} mycommand} has been defined in this example, to give italic, mono-spaced text:
\mycommand{some text}.
A listing of the contents of each file supplied as Supporting Information
should be included. For instructions on what should be included in the \section*{Acknowledgements}
Supporting Information as well as how to prepare this material for
publications, refer to the journal's Instructions for Authors. Please use ``The authors thank \ldots'' rather than ``The authors would like to
thank \ldots''.
The following files are available free of charge.
\begin{itemize} \section*{Supporting information}
\item Filename-1: brief description
\item Filename-2: brief description A listing of the contents of each file supplied as Supporting Information
\end{itemize} should be included. For instructions on what should be included in the
Supporting Information as well as how to prepare this material for
\printbibliography publications, refer to the journal's Instructions for Authors.
\newpage The following files are available free of charge.
\begin{itemize}
\rule{0.05in}{1.75in}% \item Filename-1: brief description
\begin{minipage}[b][1.75in]{3.25in} \item Filename-2: brief description
\sffamily \end{itemize}
\frenchspacing
\printbibliography
Some journals require a graphical entry for the Table of Contents. This
should be laid out ``print ready'' so that the sizing of the text is correct. \newpage
The space available depends on the journal: J. Am. Chem. Soc. allows 3.25 in \rule{0.05in}{1.75in}%
by 1.75 in and requires sanserif text. Some journals want different sizes: \begin{minipage}[b][1.75in]{3.25in}
you can easily adjust here. \sffamily
\frenchspacing
The two rules either side of the content are there to help judge the height
of your material: they may be deleted once not required. Some journals require a graphical entry for the Table of Contents. This
should be laid out ``print ready'' so that the sizing of the text is correct.
\end{minipage}%
\rule{0.05in}{1.75in} The space available depends on the journal: J. Am. Chem. Soc. allows 3.25 in
by 1.75 in and requires sanserif text. Some journals want different sizes:
\end{document} you can easily adjust here.
The two rules either side of the content are there to help judge the height
of your material: they may be deleted once not required.
\end{minipage}%
\rule{0.05in}{1.75in}
\end{document}