finished report

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main.tex

@@ -1,285 +1,250 @@
-%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
-%% This is a "template" model document for submission to the
-%% American Chemical Society (ACS).
-%%
-%% The guidance here contains information about how you may wish to
-%% modify it to match the requirements of various ACS journals. The
-%% ACS do *not* typeset accepted articles using LaTeX, so there is
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-%%
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-%%
-%% Released under the Creative Commons 0 license
-%% https://creativecommons.org/public-domain/cc0/
-%% 
-%% Copyight (c) 2025 Joseph Wright
-%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
-\documentclass[letterpaper]{article}
-
-%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
-%% Font setup - delete if you are using LuaLaTeX
-%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
-\usepackage[T1]{fontenc}
-
-%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
-%% Adjust the margins and allow for line spacing
-%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
-\usepackage{geometry}
-\geometry{margin = 1in}
-\usepackage{setspace}
-
-%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
-%% Reference support
-%%
-%% The recommended method for producing the reference section is
-%% to use biblatex. If you wish to use a classical BibTeX
-%% approach, this is easiest to achieve using the achemso package.
-%% In that case, you should remove the biblatex lines.
-%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
-% You can adjust the printing of DOI, article title, etc. using
-% package options, e.g. "doi = true"; see the biblatex manual for
-% details of adjusting the number of authors printed, e.g.
-% "maxnames = 15" to print no more than 15 authors.
-\usepackage[style = chem-acs]{biblatex}
-\addbibresource{acs-template.bib}
-% If you are using classical BibTeX, remove the above lines and 
-% uncomment:
-%\usepackage{achemso}
-
-%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
-%% Graphic inclusion and scheme and chart support
-%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
-\usepackage{graphicx}
-\usepackage{float}
-\newfloat{scheme}{htbp}{los}
-\floatname{scheme}{Scheme}
-\floatname{chart}{Chart}
-\newfloat{graph}{htbp}{loh}
-
-%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
-%% Common support packages
-%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
-\usepackage{chemformula} % Formulas using \ch{}
-% or
-\usepackage[version = 4]{mhchem} % Formulas using \ce{}
-
-%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
-%% Many journals require that sections are unnumbered: this 
-%% is activated here
-%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
-\setcounter{secnumdepth}{-1}
-
-%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
-%% Place any additional macros here.  Please use \newcommand* where
-%% possible, and avoid layout-changing macros (which are not used
-%% when typesetting).
-%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
-\newcommand*\mycommand[1]{\texttt{\emph{#1}}}
-
-%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
-%% Author and title data:
-%% the authblk package is currently the simplest way to provide this
-%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
-\usepackage{authblk}
-\author[1]{Shivam Tripathi}
-\author[1]{Keshav Anand}
-\affil[1]{Plano East}
-
-\title{A ``template'' model document for submission to the
-  American Chemical Society (ACS)}
-% Use the \date command for email address(s) of corresponding authors
-
-
-\begin{document}
-
-\maketitle
-
-\begin{abstract}
-  This is an example document for creating \LaTeX{} submissions to the American
-  Chemical Society (ACS) for publication. As ACS does not use \LaTeX{} for
-  typesetting accepted manuscripts, this template does not seek to
-  reproduce the appearance of a published paper.
-\end{abstract}
-
-\section*{Keywords}
-
-Some journals require keywords: these normally should be given immediately
-after the abstract.
-
-\section*{Abbreviations}
-
-Some journals require a list of abbreviations: these normally should be given
-immediately after the keyswords (if required).
-
-%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
-%% Start the main part of the manuscript here.
-%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
-\section{Introduction}
-
-This is a paragraph of text to fill the introduction of the demonstration file. 
-
-\section{Results and discussion}
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-follows (Scheme~\ref{sch:example}). As illustrated, the float is ``here'' if
-possible.
-\begin{scheme}
-  \centering
-  Your scheme graphic would go here: PDF graphics are recommended.
-  %\includegraphics{graphic}
-  \caption{An example scheme}
-  \label{sch:example}
-\end{scheme}
-
-\begin{figure}
-  \centering
-  A standard figure environment.
-  \label{fgr:example}
-\end{figure}
-
-The use of the different floating environments is not required, but it is
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-\pi r^2 \]
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-\begin{equation}
-  \frac{\mathrm{d}}{\mathrm{d}x} \, r^2 = 2r \label{eqn:example}
-\end{equation}
-This can also be used to have equations containing graphical content. To align
-the equation number with the middle of the graphic, rather than the bottom, a
-minipage may be used.
-\begin{equation}
-  \begin{minipage}[c]{0.80\linewidth}
-    \centering
-    As illustrated here, the width of \\
-    the minipage needs to allow some  \\
-    space for the number to fit in to.
-    %\includegraphics{graphic}
-  \end{minipage}
-  \label{eqn:graphic}
-\end{equation}
-
-\section{Experimental}
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-The usual experimental details should appear here. This could include a table,
-which can be referenced as Table~\ref{tbl:example}. Notice that the caption is
-positioned at the top of the table.
-\begin{table}
-  \caption{An example table}
-  \label{tbl:example}
-  \centering
-  \begin{tabular}{ll}
-    \hline
-    Header one  & Header two  \\
-    \hline
-    Entry one   & Entry two   \\
-    Entry three & Entry four  \\
-    Entry five  & Entry five  \\
-    Entry seven & Entry eight \\
-    \hline
-  \end{tabular}
-\end{table}
-
-Adding notes to tables can be complicated. Perhaps the easiest method is to
-generate these using the basic \texttt{\textbackslash textsuperscript} and
-\texttt{\textbackslash emph} macros, as illustrated (Table~\ref{tbl:notes}).
-\begin{table}
-  \caption{A table with notes}
-  \label{tbl:notes}
-  \centering
-  \begin{tabular}{ll}
-    \hline
-    Header one                            & Header two \\
-    \hline
-    Entry one\textsuperscript{\emph{a}}   & Entry two  \\
-    Entry three\textsuperscript{\emph{b}} & Entry four \\
-    \hline
-  \end{tabular}
-
-  \textsuperscript{\emph{a}} Some text;
-  \textsuperscript{\emph{b}} Some more text.
-\end{table}
-
-The example file also loads the optional \textsf{chemformula} and
-\textsf{mhchem} packages, so that formulas are easy to input:
-\texttt{\textbackslash ce\{H2SO4\}} gives \ce{H2SO4}. The two have similar
-syntax but authors may prefer one or the other.
-
-The use of new commands should be limited to simple things which will not
-interfere with the production process. For example, \texttt{\textbackslash
-mycommand} has been defined in this example, to give italic, mono-spaced text:
-\mycommand{some text}.
-
-\section*{Acknowledgements}
-
-Please use ``The authors thank \ldots'' rather than ``The authors would like to
-thank \ldots''.
-
-\section*{Supporting information}
-
-A listing of the contents of each file supplied as Supporting Information
-should be included. For instructions on what should be included in the
-Supporting Information as well as how to prepare this material for
-publications, refer to the journal's Instructions for Authors.
-
-The following files are available free of charge.
-\begin{itemize}
-  \item Filename-1: brief description
-  \item Filename-2: brief description
-\end{itemize}
-
-%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
-%% If you are using classical BibTeX rather than biblatex,
-%% remove the \printbibliography and uncomment the \bibliograpy one
-%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
-\printbibliography
-%\bibliography{acs-template.bib}
-
-\newpage
-
-\rule{0.05in}{1.75in}%
-\begin{minipage}[b][1.75in]{3.25in}
-  \sffamily
-  \frenchspacing
-
-  Some journals require a graphical entry for the Table of Contents. This
-  should be laid out ``print ready'' so that the sizing of the text is correct.
-
-  The space available depends on the journal: J. Am. Chem. Soc. allows 3.25 in
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-  you can easily adjust here.
-  
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-  of your material: they may be deleted once not required.
-  
-\end{minipage}%
-\rule{0.05in}{1.75in}
-
-\end{document}
+\documentclass[letterpaper]{article}
+
+\usepackage[T1]{fontenc}
+
+
+\usepackage{geometry}
+\geometry{margin = 1in}
+\usepackage{setspace}
+
+\usepackage{chemfig}
+
+\usepackage[style = chem-acs]{biblatex}
+\addbibresource{references.bib}
+
+\usepackage{graphicx}
+\usepackage{float}
+\newfloat{scheme}{htbp}{los}
+\floatname{scheme}{Scheme}
+\floatname{chart}{Chart}
+\newfloat{graph}{htbp}{loh}
+
+\usepackage{tabularx}
+
+
+\usepackage{chemformula} % Formulas using \ch{}
+% or
+\usepackage[version = 4]{mhchem} % Formulas using \ce{}
+
+
+\setcounter{secnumdepth}{-1}
+
+\newcommand*\mycommand[1]{\texttt{\emph{#1}}}
+
+\usepackage{authblk}
+\author[1]{Shivam Tripathi}
+\author[1]{Keshav Anand}
+\affil[1]{Plano East Senior High School, Plano, TX, United States}
+
+\title{Acid-Catalyzed Tandem Hydrolysis--Esterification of Acetylsalicylic Acid 
+from Commerical Aspirin Tablets to Form Methyl Salicylate}
+% Use the \date command for email address(s) of corresponding authors
+
+
+\begin{document}
+
+\maketitle
+
+\begin{abstract}
+Methyl salicylate was synthesized from commercial aspirin tablets via an acid-catalyzed 
+  tandem hydrolysis–esterification sequence. Acetylsalicylic acid (ASA) was extracted 
+  from the tablet matrix into methanol and reacted under reflux with a catalytic 
+  volume of \ce{H2SO4}. This one-pot method facilitates simultaneous deacetylation 
+  and Fischer esterification, bypassing the isolation of a salicylic acid intermediate. 
+  The resulting methyl salicylate was isolated via aqueous quenching and 
+  liquid--liquid extraction. Crude product purification was achieved through 
+  neutralization with saturated \ce{NaHCO3} and drying over anhydrous \ce{MgSO4}. 
+  This synthesis demonstrates an efficient, high-yield conversion of a common 
+  pharmaceutical precursor into a high-value fragrance ester, highlighting 
+  fundamental principles of equilibrium-driven organic transformations and 
+  multistep one-pot synthesis.
+\end{abstract}
+
+
+\section{Introduction}
+
+Acetylsalicylic acid (ASA), \ch{C9H8O4}, is a synthetic organic derivative of salicylic acid 
+and is commonly known as aspirin~\cite{Fijakowski2022}.\\
+\begin{figure}[ht]
+  \centering
+  \vspace{1em} % Adds space above the molecule
+  \chemfig{*6(-=-(-O-[:-30](=[:-90]O)-[:+30]CH_3)=([:60]-[:90](=[:150]O)-[:30]OH)-=)}
+  \vspace{1em} % Adds space below the molecule
+  \caption{Chemical structure of ASA}
+  \label{fig:asa-structure}
+\end{figure}
+
+Commercial aspirin is commonly synthesized from salicylic acid through Eq~\ref{eq:aspirin-syn},
+and the two molecules differ by an ester group (\ch{-OCOCH3})~\cite{Sneader2000}.
+\begin{equation}
+    \ce{C7H6O3 + C4H6O3 ->[H2SO4] C9H8O4 + CH3COOH}
+    \label{eq:aspirin-syn}
+\end{equation} \\
+Another common derivative product of salicylic acid is methyl salicylate, \ch{C8H8O3}, commonly referred to 
+as wintergreen oil. Methyl salicylate is commonly used in edibles (e.g. gum, mints), perfumes, and pain-relief 
+ointments (e.g. Icy Hot, BenGay)~\cite{Guo2022}. Methyl salicylate also differs with salicylic acid by a single ester group and 
+has simply been esterified differently than ASA.\\
+
+\begin{figure}[ht]
+  \centering
+  \vspace{1em} % Adds space above the molecule
+  \chemfig{*6(-=-(-OH)=([:60]-[:90](=[:150]O)-[:30]O-[:+90]CH_3)-=)}
+  \vspace{1em} % Adds space below the molecule
+  \caption{Chemical structure of methyl salicylate}
+  \label{fig:methyl-salicylate}
+\end{figure}
+
+Due to the similarity between the two molecules, ASA can be reacted to synthesize methyl salicylate~\cite{Hartel2009,nilered2017aspirin}. 
+The purpose of this experiment was to convert acetylsalicylic acid obtained from 
+commercial aspirin tablets into methyl salicylate through acid-catalyzed esterification 
+in methanol under reflux conditions.
+
+
+\section{Results and discussion}
+
+\subsection {Extraction and Solvation of ASA}
+
+The synthesis began with the mechanical breakdown of commercial aspirin tablets (500~mg ASA/tablet) using a mortar and pestle. The resulting powder was digested in an excess of methanol for one hour with constant stirring.  \\
+
+The heterogeneous mixture was subsequently clarified via filtration through a cellulose-based filter. This step effectively isolated the soluble ASA and miscible plasticizers from the insoluble structural excipients and pigments (Table~\ref{tbl:solubility}).
+
+\renewcommand{\arraystretch}{1.5} % Adds vertical space between rows
+\begin{table}[ht]
+  \caption{Methanol Solubility/Miscibility Profile of Tablet Components}
+  \label{tbl:solubility}
+  \centering
+  \begin{tabularx}{\textwidth}{l X l}
+    \hline
+    \textbf{Component Category} & \textbf{Specific Ingredients} & \textbf{Solubility in $\text{CH}_3\text{OH}$} \\
+    \hline
+    \textbf{Active Ingredient} & Acetylsalicylic Acid (ASA) & Soluble \\
+    \textbf{Binders / Fillers} & Corn Starch, Powdered Cellulose & Insoluble \\
+    \textbf{Coating Agents} & Carnauba Wax, Shellac, Hypromellose & Insoluble / Sparingly \\
+    \textbf{Plasticizers} & Propylene Glycol, Triacetin & Miscible \\
+    \textbf{Pigments / Lakes} & Titanium Dioxide, D\&C Red \#7, FD\&C Blue \#2, FD\&C Red \#40 & Insoluble \\
+    \hline
+  \end{tabularx}
+\end{table}
+
+
+\subsection{\ce{H2SO4} Catalyzed Tandem Hydrolysis--Esterification}
+
+The conversion of ASA to methyl salicylate proceeds via a one-pot tandem sequence (Scheme~\ref{sch:mechanism}). Concentrated \ce{H2SO4} serves as a Brønsted acid catalyst, activating the carbonyl groups toward nucleophilic attack by methanol, and as a dehydrating agent to shift the equilibrium.
+
+\begin{scheme}[H]
+  \centering
+  \small
+  \setchemfig{atom sep=2.0em, compound sep=5em, nodesep=2pt}
+  
+  % Wrapper to ensure vertical alignment of the three main components
+  \begin{tabular}{ccc}
+    \chemname{
+      \chemfig{*6(-=-(-O-[:-30](=[:-90]O)-[:+30]CH_3)=([:60]-[:90](=[:150]O)-[:30]OH)-=)}
+    }{\footnotesize Acetylsalicylic Acid}
+    & 
+    \parbox{2.5cm}{\centering $\xrightarrow[\Delta]{\ce{CH3OH, H2SO4}}$} 
+    & 
+    \chemname{
+      \chemfig{*6(-=-(-OH)=([:60]-[:90](=[:150]O)-[:30]O-[:+90]CH_3)-=)}
+    }{\footnotesize Methyl Salicylate}
+  \end{tabular}
+
+  \vspace{1.5em}
+  \caption{Tandem deacetylation and Fischer esterification sequence.}
+  \label{sch:mechanism}
+\end{scheme}
+
+The transformation encompasses two concurrent equilibrium-driven processes:
+
+\begin{enumerate}
+    \item \textbf{Acid-Catalyzed Solvolysis:} The acetoxy group undergoes transesterification with methanol to yield salicylic acid and methyl acetate (Eq~\ref{eq:solvolysis}).
+    \item \textbf{Fischer Esterification:} The carboxylic acid is esterified by the methanol solvent (Eq~\ref{eq:fischer}).
+\end{enumerate}
+
+\begin{equation}
+    \ce{R-OCOCH3 + CH3OH <=>[H+] R-OH + CH3COOCH3}
+    \label{eq:solvolysis}
+\end{equation}
+
+\begin{equation}
+    \ce{Ar-COOH + CH3OH <=>[H+] Ar-COOCH3 + H2O}
+    \label{eq:fischer}
+\end{equation}
+
+To drive the reaction toward the methyl salicylate product, a substantial stoichiometric excess of methanol was employed, utilizing Le Chatelier's principle to overcome the reversible nature of the esterification.
+
+\subsection{Kinetic and Thermodynamic Analysis}
+
+The transformation efficiency of the tandem hydrolysis--esterification is determined by the interplay between reaction rate and equilibrium position.
+
+\subsubsection{Thermal Activation and Collision Theory}
+The reflux duration is required to provide the activation energy ($E_{a}$) necessary for the nucleophilic attack on the sterically hindered aryl ester. According to the Arrhenius relationship, the rate constant $k$ increases exponentially with temperature:
+\begin{equation}
+    k = Ae^{-E_{a}/RT}
+\end{equation}
+Operating at the boiling point of the solvent increases the frequency of effective collisions and facilitates the formation of the required carbocation intermediates. 
+
+Furthermore, by employing a vast molar excess of methanol, the system effectively follows pseudo-first-order kinetics. Under these conditions, the concentration of the alcohol remains negligible in its variation, and the rate depends solely on the concentration of the limiting aspirin precursor:
+\begin{equation}
+    -\frac{d[\text{ASA}]}{dt} = k'[\text{ASA}] \implies [\text{ASA}]_{t} = [\text{ASA}]_{0}e^{-k't}
+\end{equation}
+
+\subsubsection{Equilibrium Shifts and Chemical Potential}
+As a reversible process, the yield is limited by the equilibrium constant ($K$). Because the esterification step is endothermic ($\Delta H^\circ > 0$), the application of heat shifts the equilibrium toward the products. This temperature dependence is quantified by the Van't Hoff equation:
+\begin{equation}
+    \frac{d \ln K}{dT} = \frac{\Delta H^\circ}{RT^{2}}
+\end{equation}
+
+The high reactant-to-substrate ratio further ensures that the reaction quotient ($Q$) remains lower than $K$ throughout the process. This maintains a negative Gibbs free energy ($\Delta G$), driving the reaction toward the formation of methyl salicylate:
+\begin{equation}
+    \Delta G = \Delta G^\circ + RT \ln Q
+\end{equation}
+The combination of thermal input and stoichiometric bias effectively overcomes the reversible nature of the Fischer esterification.
+\subsection{Work-up and Purification}
+
+Following reflux, the reaction was quenched in ice-cold distilled water. Methyl salicylate ($\rho \approx 1.17$ g/mL) was isolated as the organic phase via liquid--liquid extraction. Residual acidic species (\ce{H2SO4}, \ce{CH3COOH}) were neutralized using saturated \ce{NaHCO3}:
+
+\begin{equation}
+    \ce{H2SO4(aq) + 2NaHCO3(aq) -> Na2SO4(aq) + 2CO2(g) + 2H2O(l)}
+\end{equation}
+
+The organic extract was dried over anhydrous \ce{MgSO4} and filtered to yield the pure essential oil.
+
+\section{Experimental}
+
+\subsection{Materials and Reagents}
+The starting material consisted of 50 Bayer Extra Strength aspirin tablets (500~mg ASA per tablet). The reaction used ACS-grade methanol and 96\% \ce{H2SO4}. A saturated solution of commercial iodized salt was used for the salting-out step.
+
+\subsection{Extraction and Filtration}
+The 50 tablets had a total initial mass of 30.148~g. These were crushed using a mortar and pestle into a fine powder. After grinding, 28.114~g of the powder was recovered, meaning some material was lost in the mortar. Based on the ratio of the original 25.000~g of ASA in the 30.148~g bulk, the actual amount of ASA moved into the beaker was 23.313~g (0.129~mol).
+
+This powder was stirred in 190~mL of methanol for an hour. The mixture was then poured through a coffee filter to strain out the starch and cellulose binders. The resulting liquid had a faint pink tint, likely from the dyes used in the tablet coating.
+
+\subsection{Tandem Reaction and Reflux}
+The filtered liquid was poured into a 250~mL round-bottom flask. When the 5~mL of 96\% \ce{H2SO4} was added dropwise, the flask became hot to the touch and the liquid boiled locally where the acid hit. The flask was set up with a water-cooled condenser and boiled at a steady reflux for 60~min. During this time, the liquid lost its clarity and became slightly murky.
+
+\subsection{Isolation and Salting-Out}
+After boiling, the liquid was evaporated down to about 100~mL and then poured into 100~mL of ice-cold water. To help the oil separate from the water, 10~mL of saturated salt water was added. Because the total volume was too high for a single small container, the mixture was split into two 125~mL separatory funnels. In both funnels, the wintergreen oil sank to the bottom as a dense layer. These two layers were drained and combined.
+
+\subsection{Purification and Neutralization}
+The crude oil was washed twice with 50~mL of saturated \ce{NaHCO3} and seperated throguh gravity seperation. Both times, the mixture fizzed a lot as the acid was neutralized, so the funnel had to be vented constantly while shaking. This process removed the leftover sulfuric acid and the acetic acid byproduct, and the fizzy gas was the \ce{CO2} resulting from the neutralization reaction.
+
+\subsection{Theoretical Yield Analysis}
+The final oil was dried with anhydrous \ce{MgSO4} until it looked clear and then filtered through a cotton plug. Based on the starting amount of 23.313~g of ASA, the theoretical yield of methyl salicylate is:
+
+\begin{equation}
+    \text{Mass}_{\text{theoretical}} = 0.129\text{ mol} \times 152.15\text{ g/mol} = 19.627\text{ g}
+\end{equation}
+
+The final product was a clear oil with a very strong wintergreen scent. While the final yield was not recorded, the mass of final product was 
+much lower than 19.627 g, and the researchers estimate the percent yield to be near 10\%. This low yield is likely attrributed to the 
+equillibrium nature of the reaction. Additionally, substantial oil was lost in seperation to prevent accidental 
+passage of the aqueous layer.
+
+
+
+\printbibliography
+
+
+
+\end{document}

references.bib

@@ -0,0 +1,68 @@
+@article{Fijakowski2022,
+  title = {Acetylsalicylic Acid–Primus Inter Pares in Pharmacology},
+  volume = {27},
+  ISSN = {1420-3049},
+  url = {http://dx.doi.org/10.3390/molecules27238412},
+  DOI = {10.3390/molecules27238412},
+  number = {23},
+  journal = {Molecules},
+  publisher = {MDPI AG},
+  author = {Fijałkowski,  Łukasz and Skubiszewska,  Magdalena and Grześk,  Grzegorz and Koech,  Frankline Kiptoo and Nowaczyk,  Alicja},
+  year = {2022},
+  month = Dec,
+  pages = {8412}
+}
+
+@article{Sneader2000,
+  title = {The discovery of aspirin: a reappraisal},
+  volume = {321},
+  ISSN = {1468-5833},
+  url = {http://dx.doi.org/10.1136/bmj.321.7276.1591},
+  DOI = {10.1136/bmj.321.7276.1591},
+  number = {7276},
+  journal = {BMJ},
+  publisher = {BMJ},
+  author = {Sneader,  W.},
+  year = {2000},
+  month = Dec,
+  pages = {1591–1594}
+}
+
+@article{Guo2022,
+  title = {Safety and efficacy of compound methyl salicylate liniment for topical pain: A multicenter real-world study in China},
+  volume = {13},
+  ISSN = {1663-9812},
+  url = {http://dx.doi.org/10.3389/fphar.2022.1015941},
+  DOI = {10.3389/fphar.2022.1015941},
+  journal = {Frontiers in Pharmacology},
+  publisher = {Frontiers Media SA},
+  author = {Guo,  Jie and Hu,  Xiaolei and Wang,  Jing and Yu,  Bin and Li,  Juan and Chen,  Jianting and Nie,  Xiaoli and Zheng,  Zhijian and Wang,  Shixuan and Qin,  Qun},
+  year = {2022},
+  month = Oct 
+}
+
+@article{Hartel2009,
+  title = {Preparation of Oil of Wintergreen from Commercial Aspirin Tablets. A Microscale Experiment Highlighting Acyl Substitutions},
+  volume = {86},
+  ISSN = {1938-1328},
+  url = {http://dx.doi.org/10.1021/ed086p475},
+  DOI = {10.1021/ed086p475},
+  number = {4},
+  journal = {Journal of Chemical Education},
+  publisher = {American Chemical Society (ACS)},
+  author = {Hartel,  Aaron M. and Hanna,  James M.},
+  year = {2009},
+  month = Apr,
+  pages = {475}
+}
+
+@online{nilered2017aspirin,
+  author       = {NileRed},
+  title        = {Turning aspirin pills into mint flavor},
+  year         = {2017},
+  month        = jul,
+  day          = {17},
+  organization = {YouTube},
+  url          = {https://www.youtube.com/watch?v=3NN9IUvrKi4},
+  note         = {YouTube video, 10.7M subscribers, 2,057,102 views, accessed 2026-05-12}
+}