diff --git a/main.pdf b/main.pdf index b1bf45d..3034ae1 100644 Binary files a/main.pdf and b/main.pdf differ diff --git a/main.tex b/main.tex index fe69a0b..fd849e2 100644 --- a/main.tex +++ b/main.tex @@ -1,61 +1,17 @@ -%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% -%% This is a "template" model document for submission to the -%% American Chemical Society (ACS). -%% -%% The guidance here contains information about how you may wish to -%% modify it to match the requirements of various ACS journals. The -%% ACS do *not* typeset accepted articles using LaTeX, so there is -%% no specific class required. -%% -%% This template deliberately does *not* seek to reproduce -%% the layout of the typeset journal: this is explicitly not -%% required by the ACS for LaTeX submissions. -%% -%% Please report any issues with the template at -%% https://github.com/josephwright/acs-template/issues -%% -%% Released under the Creative Commons 0 license -%% https://creativecommons.org/public-domain/cc0/ -%% -%% Copyight (c) 2025 Joseph Wright -%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% \documentclass[letterpaper]{article} -%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% -%% Font setup - delete if you are using LuaLaTeX -%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% \usepackage[T1]{fontenc} -%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% -%% Adjust the margins and allow for line spacing -%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% + \usepackage{geometry} \geometry{margin = 1in} \usepackage{setspace} \usepackage{chemfig} -%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% -%% Reference support -%% -%% The recommended method for producing the reference section is -%% to use biblatex. If you wish to use a classical BibTeX -%% approach, this is easiest to achieve using the achemso package. -%% In that case, you should remove the biblatex lines. -%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% -% You can adjust the printing of DOI, article title, etc. using -% package options, e.g. "doi = true"; see the biblatex manual for -% details of adjusting the number of authors printed, e.g. -% "maxnames = 15" to print no more than 15 authors. \usepackage[style = chem-acs]{biblatex} -\addbibresource{acs-template.bib} -% If you are using classical BibTeX, remove the above lines and -% uncomment: -%\usepackage{achemso} +\addbibresource{references.bib} -%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% -%% Graphic inclusion and scheme and chart support -%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% \usepackage{graphicx} \usepackage{float} \newfloat{scheme}{htbp}{los} @@ -63,30 +19,16 @@ \floatname{chart}{Chart} \newfloat{graph}{htbp}{loh} -%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% -%% Common support packages -%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% + \usepackage{chemformula} % Formulas using \ch{} % or \usepackage[version = 4]{mhchem} % Formulas using \ce{} -%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% -%% Many journals require that sections are unnumbered: this -%% is activated here -%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% + \setcounter{secnumdepth}{-1} -%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% -%% Place any additional macros here. Please use \newcommand* where -%% possible, and avoid layout-changing macros (which are not used -%% when typesetting). -%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% \newcommand*\mycommand[1]{\texttt{\emph{#1}}} -%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% -%% Author and title data: -%% the authblk package is currently the simplest way to provide this -%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% \usepackage{authblk} \author[1]{Shivam Tripathi} \author[1]{Keshav Anand} @@ -112,7 +54,7 @@ from Commerical Asprin Tablets to Form Methyl Salicylate} \section{Introduction} Acetylsalicylic acid (ASA), \ch{C9H8O4}, is a synthetic organic derivative of salicylic acid -and is commonly known as aspirin.\\ +and is commonly known as aspirin~\cite{Fijakowski2022}.\\ \begin{figure}[ht] \centering \vspace{1em} % Adds space above the molecule @@ -123,15 +65,15 @@ and is commonly known as aspirin.\\ \end{figure} Commercial aspirin is commonly synthesized from salicylic acid through Eq~\ref{eq:aspirin-syn}, -and the two molecules differ by an ester group (\ch{-OCOCH3}). +and the two molecules differ by an ester group (\ch{-OCOCH3})~\cite{Sneader2000}. \begin{equation} \ce{C7H6O3 + C4H6O3 ->[H2SO4] C9H8O4 + CH3COOH} \label{eq:aspirin-syn} \end{equation} \\ Another common derivative product of salicylic acid is methyl salicylate, \ch{C8H8O3}, commonly referred to as wintergreen oil. Methyl salicylate is commonly used in edibles (e.g. gum, mints), perfumes, and pain-relief -ointments (e.g. Icy Hot, BenGay). Methyl salicylate also differs with salicylic acid by a single ester group and -has simply been esterified differently than ASA. \\ +ointments (e.g. Icy Hot, BenGay)~\cite{Guo2022}. Methyl salicylate also differs with salicylic acid by a single ester group and +has simply been esterified differently than ASA.\\ \begin{figure}[ht] \centering @@ -142,7 +84,7 @@ has simply been esterified differently than ASA. \\ \label{fig:methyl-salicylate} \end{figure} -Due to the similarity between the two molecules, ASA can be reacted to synthesize methyl salicylate. +Due to the similarity between the two molecules, ASA can be reacted to synthesize methyl salicylate~\cite{Hartel2009}. The purpose of this experiment was to convert acetylsalicylic acid obtained from commercial aspirin tablets into methyl salicylate through acid-catalyzed esterification in methanol under reflux conditions. @@ -276,12 +218,7 @@ The following files are available free of charge. \item Filename-2: brief description \end{itemize} -%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% -%% If you are using classical BibTeX rather than biblatex, -%% remove the \printbibliography and uncomment the \bibliograpy one -%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% \printbibliography -%\bibliography{acs-template.bib} \newpage diff --git a/references.bib b/references.bib new file mode 100644 index 0000000..13b1089 --- /dev/null +++ b/references.bib @@ -0,0 +1,57 @@ +@article{Fijakowski2022, + title = {Acetylsalicylic Acid–Primus Inter Pares in Pharmacology}, + volume = {27}, + ISSN = {1420-3049}, + url = {http://dx.doi.org/10.3390/molecules27238412}, + DOI = {10.3390/molecules27238412}, + number = {23}, + journal = {Molecules}, + publisher = {MDPI AG}, + author = {Fijałkowski, Łukasz and Skubiszewska, Magdalena and Grześk, Grzegorz and Koech, Frankline Kiptoo and Nowaczyk, Alicja}, + year = {2022}, + month = Dec, + pages = {8412} +} + +@article{Sneader2000, + title = {The discovery of aspirin: a reappraisal}, + volume = {321}, + ISSN = {1468-5833}, + url = {http://dx.doi.org/10.1136/bmj.321.7276.1591}, + DOI = {10.1136/bmj.321.7276.1591}, + number = {7276}, + journal = {BMJ}, + publisher = {BMJ}, + author = {Sneader, W.}, + year = {2000}, + month = Dec, + pages = {1591–1594} +} + +@article{Guo2022, + title = {Safety and efficacy of compound methyl salicylate liniment for topical pain: A multicenter real-world study in China}, + volume = {13}, + ISSN = {1663-9812}, + url = {http://dx.doi.org/10.3389/fphar.2022.1015941}, + DOI = {10.3389/fphar.2022.1015941}, + journal = {Frontiers in Pharmacology}, + publisher = {Frontiers Media SA}, + author = {Guo, Jie and Hu, Xiaolei and Wang, Jing and Yu, Bin and Li, Juan and Chen, Jianting and Nie, Xiaoli and Zheng, Zhijian and Wang, Shixuan and Qin, Qun}, + year = {2022}, + month = Oct +} + +@article{Hartel2009, + title = {Preparation of Oil of Wintergreen from Commercial Aspirin Tablets. A Microscale Experiment Highlighting Acyl Substitutions}, + volume = {86}, + ISSN = {1938-1328}, + url = {http://dx.doi.org/10.1021/ed086p475}, + DOI = {10.1021/ed086p475}, + number = {4}, + journal = {Journal of Chemical Education}, + publisher = {American Chemical Society (ACS)}, + author = {Hartel, Aaron M. and Hanna, James M.}, + year = {2009}, + month = Apr, + pages = {475} +} \ No newline at end of file